5^th Annual Conference on Stroke and Neurological Disorders November 12-13, 2018 Amsterdam, Netherlands

Wagih El Masri WEM trained in the speciality of spinal injuries at Stoke Mandeville, Oxford, Guys Hospitals & the USA between 1971 and 1983. To date he personally treated 10,000 Patients with traumatic Spinal Injuries acute, sub-acute, rehabilitation phases as well as in the Long term. He is the author of the concept of “Physiological Instability of the Injured Spinal Cord “and an advocate for the evidence-based Active Physiological Conservative Management of the patient.

The management of traumatic spinal cord injury (TSCI) has remained controversial since the early 19th century. Better understanding of the Biomechanical Instability (BI), the development of CT and MRI; improving instrumentation & increased safety of anaesthetic resulted in a change of practice from Active Physiological Conservative Management (APCM) of the spinal injury and all its effects to a focused surgical management of the spine often with little attention to the multi-system physiological impairment and malfunction and the non-medical effects of cord damage. Surgical stabilisation is undoubtedly beneficial to patients with injury of the bony spine with intact neurology. Although these patients can be treated with APCM of their spinal injury, Surgery will expedite their discharge from hospital ie the patient can be discharged home within a few days of surgery. The short, medium and long term outcomes in terms of pain and range of movement of the affected region of injury are however unknown following surgery. A TSCI results in a multi-system impairment and malfunction, paralysis, sensory loss and a potential wide range of medical and non-medical complications. The injured spinal cord is Physiologically Unstable and can be further damaged by non-mechanical complications. Hypoxia, hypertension, hypotension, sepsis, hypothermia, fluid overload can easily occur causing more neurological damage. Patients require scrupulous simultaneous attention of all effects of paralysis to ensure: maximum neurological recovery, prevent complications including pain, maximum range of movement of the spine and independence to minimise cost of support in the community, safe and convenient functioning of all body systems, long term maintenance of health to minimise readmission with complications and enable patient to contribute to the society. The prognostic indications of neurological recovery following APCM have been repeatedly documented in the last seven decades. Although there are some claims that early surgery may may yield better outcomes than late surgery; there has been no attempt to compare the outcomes of surgery with those of APCM. The early prognostic indicators of neurological recovery during the first 48-72 hours of injury, the value of any initial neurological sparing however little and in particular the value of pin prick sensory sparing down to the second sacral segmental distribution of the spinal cord will be demonstrated. The insignificance of the BI, Canal encroachment and Traumatic Cord Compression as prognostic indicators of recovery provided the patient is adequately treated with APCM and the possible advantages, disadvantages, complications of Surgical Stabilisation, Surgical Decompression and APCM will be discussed.

Umur A Kayabasi, MD. Being a graduate of Istanbul Medical Faculty completed his neuron-ophthalmology clinical fellowship at Michigan State University, MI in1995. He also worked as a researcher and server at the neuron-ophthalmology department of Wills Eye Institute, Philadelphia, PA in 2007. He has been working at World Eye Hospital, Istanbul for three years. He has written chapters in different books and published and presented many clinical studies and cases.

Yavuz Selim Silay is the chairman of Istanbul Consulting Group. ICG(Istanbul Consulting Group) was founded in 2013 and provided guidance to the Turkish ministry of health as part of a World Bank project.Yavuz is currently the Co-Founder of BioCube Ä°stanbul Bioentrepreneurship & Innovation Center and Corporate Communication Director of Sumitomo Group/ Expel Ä°laç Archem Diagnostices Endmed and Diagen. He previously managed the largest distributor of Siemens Healthcare in Turkey managing 250 employees and director of Avcılar Hospital R&D Center, Chief Medical Officer of Lifematrix GmbH. Previously he worked as the Market Access & Health Policy Director for AIFD in Turkey. Yavuz previously worked as the Vice President of Ipsen pharmaceutical and Director of Teva pharmaceutical in USA managing large clinical trials as well as Investigator Initiated Trials and developing relationships with Key Opinion Leaders. Previously, Yavuz was the Associate Director at KV Pharmaceuticals and Director in Clinical Development department at Forest Laboratories. Yavuz earned his MD from the Faculty of Medicine, the University of Ankara in Ankara, Turkey. He completed a clinical internship at Baylor College of Medicine in Houston, followed by continued research training at The University of Texas MD Anderson Cancer Center in Houston. He recently completed his Executive MBA at the Olin Business School at Washington University in St. Louis. Yavuz currently resides with his wife Dr Kamile Sılay and their two daughters and one son in Ankara, Turkey.

Pharmaceutical, Biotech and Medical Device companies are constantly evaluating how innovation management can be improved and managing expectations of Key opinion leaders. To gain these critical insights for Physician Entrepreneurship, Our goal at Society of Physician Entrepreneur is to accelerate innovations in order to improve healthcare. We seek to empower doctors, other healthcare providers and entrepreneurs with the information, resources, connections, and experience they need to commercialize their ideas, inventions and discoveries. Current Trends in Physician Entrepreneurship in USA Europe. Turkey and Emrging Markets will be provided with unique cases. Dr. Yavuz Selim SILAY a global leader and seasoned expert in Physician Entrepreneurship, Government engagement, Commercial Diplomacy, Corporate Communications, Government affairs & Medical Affairs will discuss how Venture Capital and angel Invetstment networks are utilizing physician entrepreneurs to acquire these insights in a convenient, cost-effective, and compliant manner in this current changing global entrepreneurial

landscape.