Neurophysiology and Neurodegeneration

Neurophysiology is a branch of physiology and neuroscience that is concerned with the study of the functioning of the nervous system. The primary tools of basic neurophysiological research include electrophysiological recordings, for example, voltage clamp, patch clamp, extracellular single-unit recording and recording of local field potentials, as well as some of the methods of apoptogenesis, calcium imaging, and molecular biology. Neurophysiology is related to electrophysiology, neuroanatomy, psychology and mathematical neuroscience. Neurodegeneration is the process of progressive damage of structure or function of neurons, with the death of neurons. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's – occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells. As research progresses, many similarities appear that relate these diseases to one another on a sub-cellular level. Discovering these resemblances offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.

  • Demyelinating diseases                                 
  • Peripheral and autonomic neuropathy                       
  • Amyotrophic lateral sclerosis (ALS)              
  • Huntington’s diseases
  • Batten diseases
  • Prevention of dementia

 

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